Functional Health Report Understand your body. Spend your healthcare dollars wisely. Every day, your body produces skin, muscle, and bone. It churns out rich red blood that carries nutrients and oxygen to remote outposts, and it sends nerve signals skipping along thousands of miles of brain and body pathways. It also formulates chemical messengers that shuttle from one organ to another, issuing the instructions that help sustain your life. But to do all this, your body requires some raw materials. These include at least 30 vitamins, minerals, and dietary components that your body needs "but cannot manufacture on its own in sufficient amounts." If you don't eat these raw material your body becomes deficient and changes start to show up in your blood work. We call these changes "Bio Markers." By analyzing these Bio Markers your deficiencies and excesses can be determined and nutritional intervention can be recommended. So you can; Understand your nutritional deficiencies and which supplements could help you. Save time and money by purchasing only what your body needs. Enjoy peace of mind that you are not accidentally harming your self. You should get the Functional Health Report if; You want to address an existing health concern or condition. You want to optimize athletic performance. You want to reduce medications. You want to overcome an addiction. You want to get pregnant. You want to increase vitality. You're at high risk of disease. You simply want to feel better! Functional Health Report takes your blood lab data and analyzes it to help you understand what's going on inside your body. Our Functional Health Report Examines the Following Bio Markers Diabetes Screen; Glucose, Hemoglobin A1C Heart Health / Lipid Profile; Total Cholesterol, Triglyceride, HDL, LDL, VLDL, Total Cholesterol / HDL Ratio, Creatine Kinase Kidney Function Test; Creatinine, BUN, Uric Acid, BUN / Creatinine Ratio Thyroid Screen; TSH, T3 total, T3 uptake, T3 free, Reverse T3, T4 total, T4 free, T7, TPO antibody, TG antibody Anemia Screen; Red Blood count with, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelets, Iron, Ferritin (iron storage) White Blood Cell Count (Immune); Neutrophils, Lymphocytes, Monocytes, Eosinophil's, Basophils Liver Function Screen; LDH, SGOt(AST), SGPT(ALT), GGT, Total Bilirubin, Alkaline Phosphatase Blood Minerals; Sodium, Potassium, Chloride, Magnesium, Calcium, Phosphorus, Calcium / Albumin Ratio, Co2 Blood Proteins; Total Protein, Albumin, Globulin, A/G Ratio Inflammatory Markers; ESR-Erythrocyte Sed Rate, CRP C-Reactive Protein Anemia Panel Red blood cells carry oxygen to the cells of your body and Co2 away. This panel will help you know if you have the proper nutrition to build enough Red blood cells and whether or not they are being destroyed too early by some other process. The Test Includes; Red blood count with differential, Ferritin (iron storage), Serum Iron, Total iron binding capacity, Vitamin B12, Folate Reticulocyte count (immature red blood cells) Heart Health Panel Assess you risk of developing heart disease. This test includes; Total Cholesterol HDL Cholesterol LDL Cholesterol LDL Cholesterol VLDL Triglycerides Cholesterol/HDL Ratio Estimated CHD Risk Factor Vitamin D 25- hydroxyl C-Reactive Protein (high sensitivity) Homocysteine Fibrinogen Kidney Function Panel Access the health of your kidneys and their ability to filter the waste from your blood. This test includes; (BUN) Blood Urea Nitrogen BUN/Creatinine Ratio Calcium Carbon Dioxide Chloride Creatinine Glucose Potassium Sodium Liver Function Panel Accesses the function of your Liver. This test includes; Alanine Aminotransferase (ALT/SGPT) Albumin, serum Alkaline phosphatase, serum Aspartate aminotransferase (AST/SGOT) Bilirubin, direct Bilirubin, total Protein, total, serum Prostate Panel Screens for prostate cancer. This test includes; Free PSA Total PSA with % free (screen) Thyroid Function Panel This test assess the functional level of the thyroid. There are also Bio-markers that show if an Auto-immune situation is occurring and if stress is involved in diminishing Thyroid function. This test includes; TSH (Thyroid Stimulating Hormone) T3 Free Reverse T3 T4 Free TPO (Thyroid Peroxidase Antibody) TG (Thyroglobulin Antibody) Adrenal Stress Index ASI™ Abnormal adrenal rhythm can influence many functions of the body. The Adrenal Rhythm and Its Importance. The human adrenal gland does not secrete its steroid hormones at a constant level throughout the day. The hormones are actually released in a cycle, with the highest value in the morning and the lowest value at night. This 24-hour cycle is called the circadian rhythm. Energy production: Abnormal adrenal function can alter the ability of cells to produce energy for the activities of daily life. People who have a hard time rising in the morning, or who suffer from low energy throughout the day, often have abnormal adrenal rhythms and poor blood sugar regulation. The maintenance of a stable blood sugar level depends on food choice, lifestyle, adrenal function and insulin activity. The Adrenal Stress Index™ panel measures stress hormones and insulin, to help ferret out the causes of fatigue, cravings and obesity. Muscle and joint function: Abnormal adrenal rhythms are known to compromise tissue healing. Reduced tissue repair and increased tissue breakdown can lead to muscle and joint wasting with chronic pain. Bone health: The adrenal rhythm determines how well we build bone. If the night cortisol level is elevated and the morning level is too high, our bones do not rebuild well, and we are more prone to osteoporosis. Stress is the enemy of the bones. In postmenopausal women, the effect of stress worsens due to female hormone imbalances. Immune health: Various immune cells (white blood cells) cycle in and out of the spleen and bone marrow. The immune system trafficking follows the cortisol cycle. If the cycle is disrupted, especially at night, then the immune system is adversely affected. Short- and long-term stress is known to suppress the immune response in the lungs, throat, urinary tract and intestines. With the reduction in the surface antibody (called secretory IgA), the resistance to infection is reduced and allergic reactions are believed to increase. Sleep quality: In sleep deprived individuals, the mean cortisol levels are elevated, and the quiescent period is shorter. Evening cortisol level is increased in patients with insomnia, affecting the first part of the nocturnal sleep period, increasing risk for depression. Fertility: Couples with high level of stress markers are less likely to succeed in conceiving. Stress alters the brain signals that trigger the ovaries to release eggs each month, so women under non stop stress ovulate fewer eggs than less stressed women. Stress can also affect testosterone level and sperm production in men. Helping couples to de-stress while trying to conceive can impact their success rate. Memory: Sustained stress adversely affects brain function and memory processing. Too much cortisol interferes with the functioning chemicals the brain uses for its cellular intercommunication. Chronic long term stress, with increased cortisol level at night, makes it perplexing to think, organize and store new memories or retrieve long-term ones. Skin regeneration: Human skin regenerates mostly during the night. With higher night cortisol values, less skin regeneration takes place. So a normal cortisol rhythm is essential for optimal skin health. Thyroid function: The level of cortisol at the cell level controls thyroid hormone production. Often, hypothyroid symptoms such as fatigue and low body temperature are due to an adrenal maladaptation. Grain intolerance and stress response: Approximately 12% to 18% of the U.S. population suffers from a genetic intolerance to grain. A high incidence occurs in people with Celtic, Nordic, non-Caucasian and Mediterranean ethnicity. The gut becomes inflamed within 30 minutes after consuming grains, and this can lead to an adrenal stress response, increased cortisol and reduced DHEA. This test includes; 4 x cortisol Helps evaluate the stress response 2 x insulin Helps investigate blood sugar control DHEA/DHEA-S Helps determine stress adaptation Secretory IgA Helps evaluate the toll on immunity 17-OH progesterone Helps determine adrenal reserve Gluten antibodies Helps identify grain intolerance Test for Food Allergy Food Allergy Symptoms, ranging from headache and nausea to seizure and hyperactivity may occur hours or even days after the offending food has been ingested. The complete elimination of IgG positive foods may result in important improvements in symptoms of irritable bowel syndrome, autism, AD(H)D, cystic fibrosis, rheumatoid arthritis and epilepsy, as demonstrated in numerous clinical studies. This test includes; 94 common foods tested. This increase the identification of numerous offending foods. Organic Acid Test The Organic Acids Test (OAT) provides information about the body's biochemical balance by measuring metabolic byproducts (waste) in the urine. This test includes; 74 metabolites, including Creatinine, detected in the OAT can indicate vitamin and hormone metabolism, energy cycle function, intestinal wall integrity, neurotransmitter metabolites, and muscle function. Some organic compounds are produced by an overgrowth of gastrointestinal yeast or bacterial species due to impaired immune function, exposure to broad-spectrum antibiotics, or high consumption of simple carbohydrates. Amino Acid Test The Amino Acids Urine and Plasma Tests can be utilized by the medical practitioner for different purposes. Urinary amino acids are discarded by the body as excess or "waste," while amino acids present in plasma indicate availability for building structural, transport and storage proteins. Amino acids also play a role in neurotransmitter functioning, cholesterol and carbohydrate metabolism, and detoxification processes. Immune Deficiency Profile Individuals with recurrent infections, otitis media, asthma and certain genetic disorders may have an immune deficiency or imbalance contributing to their disorder. Immunodeficiency predisposes an individual to intestinal yeast overgrowth, opportunistic infection and poor health. An overactive immune system is a major contributor to severe environmental allergies and may contribute to the development of autoimmune diseases such as rheumatoid arthritis and lupus. Toxic Heavy Metal Test Heavy metals toxicity, caused by increasing levels of environmental pollution and use of chemicals in industry, is a growing threat to the health and development of our children. High levels of toxic metals deposited in body tissues and, subsequently the brain, may cause significant developmental and neurological damage. Intestinal Permeability The Intestinal Permeability Assessment is a powerful and noninvasive assessment of small intestinal absorption and barrier function in the bowel. The small intestine uniquely functions as a digestive/absorptive organ for nutrients as well as a powerful immune and mechanical barrier against excessive absorption of bacteria, food antigens, and other macromolecules. Both malabsorption and increased intestinal permeability (“leaky gut”) are associated with chronic gastrointestinal imbalances as well as many systemic disorders. Increased permeability of the small intestine can: Increase the number of foreign compounds entering the bloodstream. Allow bacterial antigens capable of cross-reacting with host tissue to enter the bloodstream, leading to auto-immune processes. Enhance the uptake of toxic compounds that can overwhelm the hepatic detoxification system and lead to an overly sensitized immune system. Increased gut permeability has been observed in a range of disorders such as: Inflammatory Bowel Disease (IBD) Food allergy Inflammatory joint disease Chronic dermatologic conditions Studies have demonstrated that the increased permeability observed in patients with ankylosing spondylitis, rheumatoid arthritis, and vasculitis may be an important factor in the pathogenesis of these disorders. Decreased permeability, on the other hand, appears as a fundamental cause of malabsorption, subsequent malnutrition, and failure to thrive. In certain disease states of the small intestine, such as gluten-sensitive enteropathy, permeability to large molecules may increase while permeability to small molecules decreases, a result of damage to the microvilli. As a result, nutrients become even less available to assist in the detoxification of antigens flooding the system. Possible causes of intestinal permeability include: Intestinal infection Ingestion of allergenic foods or toxic chemicals Deficient secretory IgA Trauma and endotoxemia NSAIDs Testing Procedure: The Intestinal Permeability Assessment directly measures the ability of two non-metabolized sugar molecules to permeate the intestinal mucosa. The patient drinks a premeasured amount of lactulose and mannitol. The degree of intestinal permeability or malabsorption is reflected in the levels of the two sugars recovered in a urine sample collected over the next 6 hours. DNA Microbial Profile Gastrointestinal (GI) function is important for general health. This includes balancing beneficial microbial flora in the gut to enhance health benefits. GI health is key in digestion, nutrient usage, and ridding the body of waste and pathogens. Poor digestion and malabsorption can lead to immune dysfunction, nutritional insufficiencies, and various disease states. Poor GI function can also lead to food allergies and other toxicities. Your intestinal tract contains significant amounts of bacteria, some beneficial, some neutral, and some that can be harmful. It is essential to know the microbial balance of your GI tract, especially if you have chronic health problems. Health enhancing intestinal bacteria serve to prevent the overgrowth of potentially harmful bacteria in the gut. Why should you use the Metametrix GI EffectsSM Stool Profiles? Requires only one, single sample collection Greater accuracy due to advanced technology DNA analysis Evaluates balance of microbes shown to contribute to weight gain Identifies drug resistance genes To maintain good health Tests for: Inflammation Immune function and gluten sensitivity Yeast Parasites Bacteria Pathogens Pharmaceutical and botanical sensitivities Cancer-preventative short chain fatty acids Pancreatic function Markers for digestion and absorption Conditions and diseases related to GI disorders: Autism spectrum disorders Food sensitivities Irritable bowel syndrome Crohn’s disease Ulcerative colitis Maldigestion from history of celiac or other autoimmune disorders Symptoms related to GI disorders: Abdominal pain Arthritis/joint pain Headaches/migraines Diarrhea or constipation Noticeable change in stool Bloating/gas Unexplained weight loss/gain Blood, mucus, or pus in stool Hives/skin rash/eczema Difficulty breathing Swollen tongue/lips Acid reflux/heartburn Chills/fever Chronic fatigue Cramping Testing for Hormone Imbalances, Female The FHP™ is used to identify menstrual cycle deficits and imbalances in progesterone, estrogen, testosterone and DHEA/DHEA-S. This panel provides a profile of the hormone fluctuations in a woman’s cycle for test-guided BHRT. The FHP™ test is most applicable in cycling women with any of the following conditions: Weight gain Functional infertility Osteoporosis Endometriosis and ovarian cysts Fibroids and fibrocystic breasts Increased risk of breast cancer Recurrent cycle-related symptoms and irregularities, such as PMS, migraines, breast tenderness, emotional and cognitive issues, insomnia and spotting It is universally accepted that there is an increased risk of proliferative disease in breast and endometrial tissue when estrogen is overly dominant. The FHP basic and expanded reports both include the follicular estrogen priming index (EΠ), which quantifies the impact of excess estradiol in menstruating women. Treatment recommendations are routinely offered in the report. Testing for Hormone Imbalances, Male At or around puberty, the important male hormone testosterone reaches adult levels. For a long time it was believed that men maintain adequate levels of testosterone throughout their lives. Many men in their ﬁfties or older, however, experience a progressive decline in their energy, vitality, sexual performance and mental capacity. This decline has been labeled “andropause.” The causes of andropause are believed to be a reduction in testosterone and other androgens. The testicles show a progressive annual drop of 1-1.5% in testosterone output after age 30. Furthermore, as men age, a 1-2% annual decline in the free fraction of testosterone and a progressive annual increase of 1-2% in both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) has been documented. The clinical manifestations of andropause usually lag ten to twenty years behind the onset of hormone decline. Statistically, andropause affects at least 40% of men of age 55 to 65, and up to 80% of those of age 65 years or more. Knowing the levels of the seven to nine hormones measured in the two male hormone panels™ helps you formulate an effective plan to relieve andropausal symptoms. Testing for Mental Health Neuro-Transmitter Testing: Your nervous system is the master controller of everything that goes on inside your body. It directs everything from life-sustaining functions such as breathing, digestion, and sleep, to emotions and learning. It’s also essential for responding to what’s going on around you. The nervous system accomplishes all of these functions using chemical signals called neurotransmitters. What do neurotransmitters do? Serotonin plays important roles in mood, sleep, and appetite. In the brain, it supports proper neural transmission and in the body, a healthy immune response and GI function. GABA is the main calming neurotransmitter in the brain and is necessary to feel calm and relaxed. Taurine is an amino acid with neurotransmitter activity that is important for proper heart function, healthy sleep, and promoting calmness. Glycine is an amino acid with neurotransmitter activity that helps calm and relax the body. Glutamate is the body’s main stimulating neurotransmitter, necessary for learning and memory. It is also released in large quantities by the activated immune system. Histamine is mostly thought of as part of allergic reactions, but it also helps control the sleep-wake cycle as well as energy and motivation. PEA is important for focus, concentration, and energy. Dopamine is responsible for feelings of pleasure and satisfaction, controls muscle function, and is a modulator of sympathetic function. Norepinephrine also known as noradrenaline, is important for mental focus, emotional stability, and your adrenal/ stress response. Epinephrine also known as adrenaline, is important for motivation, energy, mental focus, and stress response. A simple urine test collected in the privacy of your own home can identify which neurotransmitter(s) may be playing a role in your health concerns. Early Detection Cancer Screening Test : TK-1 Early Detection Cancer Screening Test : TK-1 TK-1 is a biomarker test to detect the early onset of cancer. The test should be repeated annually in individuals with low risk for cancer, and more frequently for those at higher risk. TK-1 or Thymidine Kinase-1 is an enzyme that can be found in most living cells. TK-1 is responsible for DNA duplication during cell division and DNA repair. As cancerous cells rapidly and aggressively divide, more TK-1 is released into the blood. By regularly monitoring TK-1 blood levels, early indications of cancer formation can be detected before it is too aggressive to manage.